![]() ![]() ![]() These issues could be addressed through use of pulse oximetry-based peripheral blood oxygen saturation (SpO 2)/FiO 2 (SpO 2/FiO 2) ratios, which are ubiquitously available and noninvasive. 2 These studies highlight the need for more readily available severity classification methods to facilitate early recognition, phenotyping, and assessment of therapeutic response in both patients with ARDS AHRF and patients with non-ARDS AHRF. Furthermore, there is a surprising paucity of information regarding severity of illness classification and risk stratification in patients with non-ARDS AHRF, and recent work suggests mortality rates may be comparable in patients with ARDS and non-ARDS AHRF, with similar degrees of hypoxemia. 5, 14 – 17 However, the absence of standardized practices regarding ABG use and the increasing focus on early identification and treatment of patients with AHRF limit the utility of ABG-based, reactive evaluation strategies. Several studies suggest that repeated measurements of the PaO2/FiO2 ratio 24 or more hours after ARDS onset may improve the accuracy of classification and prognosis. ![]() Inconsistent use of PaO2/FiO2 ratios may be a barrier to AHRF classification and prognostication. ![]()
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